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Feb 08, 2024

The Alzheimer’s Drug Discovery Foundation and Harrington Discovery Institute to Support Promising New Drug Development Addressing the Biology of Aging Among People with Alzheimer’s Disease

The Alzheimer’s Drug Discovery Foundation (ADDF) and the Brain Health Medicines Center of Harrington Discovery Institute at University Hospitals in Cleveland have granted ADDF-Harrington Scholar Awards to two Principal Investigators, Paul Tesar, PhD, of Case Western Reserve University, and Donald F. Weaver, MD, PhD, of University Health Network’s Krembil Research Institute.

5 questions with… Paul Tesar, recipient of the School of Medicine’s highest honor

When Dean Stan Gerson called Paul Tesar to the stage at the School of Medicine’s State of the School address last month, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics believed he’d be speaking about the Institute of Glial Sciences—a new center he’s directing. Instead, as his family smiled at him from the back of the auditorium, he made a new discovery: he was receiving the Case Medal for Excellence in Health Science Innovation, the school’s highest possible honor.

December 08, 2023

Paul Tesar (CWR ’03), PhD, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics, was awarded the school’s highest honor—the Case Medal for Excellence in Health Science Innovation—during the School of Medicine State of the School presentation on Dec. 6. 

November 2nd, 2023

Case Western Reserve University School of Medicine launches Institute for Glial Sciences

New center will target glial cells to treat neurological diseases

Case Western Reserve University has established an Institute for Glial Sciences to advance research of glial cells and their critical role in the health and diseases of the nervous systems, including multiple sclerosis, Alzheimer’s, pediatric leukodystrophies, autism spectrum disorders, Parkinson’s disease and cancer.

October 27, 2023

School of Medicine postdoctoral fellow wins coveted 2023 Eppendorf & Science Prize

Marissa Scavuzzo, a postdoctoral fellow at the Case Western Reserve University School of Medicine, has won the 2023 Eppendorf & Science Prize for Neurobiology for research in how glial cells in the intestine’s nervous system operate.

Feb 11, 2022

Paul elected as a Senior Member of the National Academy of Inventors

Congratulations to Paul for being honored as one of “the world’s best emerging academic inventors” in the 2022 class of Senior Members of the National Academy of Inventors.

Feb 10, 2022

TesarLab discovery licensed to Ionis Pharmaceuticals

Case Western Reserve University and Ionis Pharmaceuticals signed an exclusive license agreement to advance and commercialize a therapeutic approach discovered by TesarLab researchers to treat Pelizaeus-Merzbacher disease (PMD). This represents major step toward a transformational antisense medicine for PMD patients and their families.

Aug 26, 2021

Erin Cohn awarded research fellowship from NIH/NINDS

Congrats to Erin (and Augie!) on this honor. Thank you to NIH and NINDS for supporting her exciting PhD thesis project on traumatic brain injury.

 

May 12, 2020

3 Tesar lab undergrads start med school

Congrats to three undergrads who are starting med school this summer. Lucille Hu will continue at CWRU in the MD program, Baraa Nawash will attend the University of Pittsburgh in their MD program, and Lili Barbar will attend Washington University in St. Louis in their MD/PhD program.

Mar 20, 2020

Matt Elitt matches at Wash U

Congrats to Matt Elitt who matched at Washington University in St. Louis in their ophthalmology residency program!

 

Aug 1, 2019

Paul Tesar is promoted to professor

Congrats to Paul for his promotion to professor in the Department of Genetics and Genome Sciences at Case Western Reserve University.

Jul 19, 2019

The Tesar lab gives back

Artur Gevorgyan, Baraa Nawash, and Marissa Scavuzzo encourage high school students in the Akron Upward Bound program to follow their curiosity and passion for science careers.

Jun 4, 2019

Marissa Scavuzzo is awarded the New York Stem Cell Foundation Druckenmiller Fellowship

Congrats to Marissa for being awarded the NYSCF Fellowship for her project, “Understanding the cells that make up the brain inside your gut.”

May 10, 2019

Lucille Hu wins first place in CWRU’s Michelson-Morley competition

Congrats to Lucille who won first place in CWRU’s annual Michelson-Morley for undergraduates who have conducted research in the biological sciences.

May 7, 2019

Marissa Scavuzzo is selected to present at the Copenhagen Bioscience Conference

Congrats to Marissa Scavuzzo who was selected to present a short talk at the Copenhagen Bioscience Conference – Intestinal Organoids on her project “The function and regenerative capacity of enteric glia in health and disease.”

Apr 12, 2019

Baraa Nawash is awarded CWRU’s PSURG and Outstanding Scholarship in Genetics

Congrats to Baraa for being selected to continue her research this summer as part of the Provost Summer Undergraduate Research Grant (PSURG). Baraa was also selected for the Department of Biology’s Award for Outstanding Scholarship in the field of Genetics.

Apr 4, 2019

Matt Elitt wins the Doctoral Excellence Award in Genetics

The Doctoral Excellence Award in Biomedical Sciences is established to recognize outstanding graduate students in PhD programs at the School of Medicine. One student per PhD program is selected for exhibiting exceptional qualities in research, scholarship, service, and collaboration. Congrats to Matt who won the award in the Department of Genetics and Genome Sciences!

Apr 1, 2019

Marissa Scavuzzo is awarded the 2019 Lehmann Outstanding Student Award from her alma mater

Congrats to Marissa who was awarded the 2019 Lehmann Award as an outstanding graduating student in Baylor’s College of Medicine Graduate School of Biomedical Sciences. Marissa was also selected to give the commencement address at Baylor’s College of Medicine 2019 graduating class.

Mar 25, 2019

Zach Nevin matches at Johns Hopkins

Congratulations to Zach Nevin who matched at Johns Hopkins in their Pediatric Genetic Medicine Residency Program!

Jan 29, 2019

Paul Tesar is appointed to the Provost’s Strategic Planning Committee- the ‘Thinkers’

Paul Tesar is selected as a member of the Provost’s strategic planning committee. The “Thinkers” will identify and assess strategic choices for Case Western Reserve’s future.

Dec 21, 2018

Lucille Hu wins first place at the Intersections Poster Session in life sciences

Undergraduates presented their research and creative projects at the SOURCE Symposium and Poster Session. Congratulations to Lucille for winning first place in Life Sciences for her poster, “Investigating the Mechanisms of Oligodendrocyte Damage in Hypoxia-Induced White Matter Injury.”

Mar 25, 2019

Zach Nevin matches at Johns Hopkins

Congratulations to Zach Nevin who matched at Johns Hopkins in their Pediatric Genetic Medicine Residency Program!

May 11, 2017

Zach Nevin defends his thesis

Zach Nevin defends his PhD thesis titled, “Modeling Genetic Diseases of Myelin Using Patient-Derived Induced Pluripotent Stem Cells”. Zach will return to medical school to finish his MD training as part of the MSTP program at CWRU.

Aug 23, 2017

Dan Factor defends his thesis

Congratulations to Dan Factor, who defended his thesis, “Understanding epigenetic controllers of stem cell fate and function”. Dan is the 4th PhD graduate from the Tesar Lab.

Mar 13, 2017

Modeling PMD

Our newest paper on modeling Pelizaeus-Merzbacher Disease (PMD) is out today in the American Journal of Human Genetics. Lead author Zach Nevin generated panels of hiPSCs and oligodendrocytes from 12 PMD patients spanning the genetic and clinical diversity of PMD—including point mutations, duplications, triplication, and deletions of PLP1—and developed an in vitro platform for molecular and cellular characterization of all 12 mutations simultaneously. Identification of unique, as well as shared, defects in PLP1 mRNA expression and splicing, OPC development, oligodendrocyte morphology, and myelination from this study will facilitate personalized treatments in the future.

Apr 14, 2016

Paul Tesar presents at the University of Louisville

Paul Tesar presents his seminar titled “Molecular Control of Oligodendrocyte Progenitor Cell Fate and Function” at the Kentucky Spinal Cord Injury Research Center at the University of Louisville.

Apr 1, 2016

Congratulation to Dr. Tyler Miller

Congratulation to Tyler Miller of the Tesar and Rich Labs on defending his thesis, “Identifying Novel in vivo Epigenetic Dependencies in Glioblastoma”. We wish Dr. Miller the best of luck as he goes back to Medical School this summer to finish the second part of his MD/PhD.

Apr 20, 2015

Existing drugs identified as potential MS treatments

Case Western Reserve scientists discovered that two common topical drugs appear to stimulate the production of oligodendrocytes to myelinate the central nervous system. The results of their investigation, published April 20, 2015 in Nature, give scientists cautious optimism that these drugs might effectively treat this disabling disease.

Mar 31, 2015

Congratulations to Dr. Angela Lager!

Congratulations to Angela Lager of the Tesar Lab for successfully defending her thesis, “Cell Reprogramming Technologies for Treatment and Understanding of Genetic Disorders of Myelin”. Best of luck to Dr. Lager as she moves on as a postdoc at the University of Wisconsin-Madison!

Jan 21, 2015

Paul Tesar named Outstanding Young Investigator from ISSCR

The International Society for Stem Cell Research (ISSCR) has named Paul Tesar the Outstanding Young Investigator for 2015. The award “recognizes the exceptional achievements of an investigator in the early part of his or her independent career in stem cell research”. Paul will be honored with the award at the ISSCR Annual Meeting in Stockholm, Sweden in June 2015.

Jul 22, 2014

Daniel Factor wins award at Cell Symposium

Congratulations to Tesar Lab graduate student Daniel Factor who recently attended the 2014 Cell Symposium on Transcriptional Regulation in Development in Chicago. At the conference, Factor was awarded the Joy Cappel 2014 Young Investigator Award for his work recently published in Cell Stem Cell. Factor also received a poster award for his work presented at the conference.

Jun 11, 2014

Discovery of “Seed” Enhancers

Check out our newest publication in Cell Stem Cell on the discovery of “Seed” Enhancers and their role in pluripotent stem cells. The finding stemmed from a synergy between the Tesar lab’s expertise in embryonic and epiblast stem cells and the genomics expertise of the Scacheri lab. Both labs are part of the Department of Genetics and Genome Sciences at the CWRU School of Medicine.

Feb 27, 2014

Paul Tesar awarded the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics

Cleveland area philanthropists Dr. Donald and Ruth Weber Goodman have a historic commitment to Research and Case Western Reserve University. Their outstanding generosity has supported education and research programs at the schools of medicine and dental medicine at CWRU. They have established two professorships, one of which was awarded to Paul Tesar.

Feb 26, 2014

Tesar lab awarded new grant from NINDS to advance novel therapeutics for multiple sclerosis

The Tesar lab was recently awarded a grant from the National Institute of Neurological Disorders and Stroke to advance therapeutics for multiple sclerosis. The Tesar lab’s expertise in stem cell biology and high throughput screening provides a unique opportunity to discover innovative therapeutics that could halt devastating diseases.

Apr 14, 2013

Discovery of induced-oligodendrocyte progenitors holds great promise for medicine

The Tesar lab has unlocked the potential to produce oligodendrocyte progenitors through a novel technique. This technique, published in Nature Biotechnology, involves directly converting fibroblasts into oligodendrocyte progenitors.

Feb 28, 2013

Are online classes the wave of the future?

Paul Tesar was recently filmed in a RENEW online course. The RENEW initiative is focused on collecting videotaped courses and sharing these courses with students all over the world. Paul was elated to be part of the initiative by sharing his session on reprogramming technology. Paul hopes to make contagious his passion for science and inspire the next generation of scientists.

Feb 28, 2013

Tesar lab graduate student Angela Lager awarded training fellowship

Congratulations to Angela Lager for being awarded an Individual Training Fellowship supported by the National Institute of Neurological Disorders and Stroke (NINDS).

Feb 28, 2013

Zach Nevin is awarded a project grant from the PMD Foundation

MD/PhD student Zach Nevin is awarded the James Y Garbern Research Project Grant to conduct his work on PMD patient specific induced pluripotent stem cell lines.

Jan 8, 2013

Paul Tesar visits the University of Edinburgh in Scotland

Paul Tesar was invited to speak at the MRC Centre for Regenerative Medicine at the University of Edinburgh in Scotland. His talk was titled, “Stem cell and reprogramming technologies for the study and treatment of myelin diseases”. Paul is grateful to his colleagues and friends at the University of Edinburgh and hopes to return in the near future.

Apr 22, 2012

Tesar and Scacheri lab retreat 2012

The Tesar and Scacheri labs traveled to a lodge in Logan, Ohio for their First Annual Lab Retreat. The event consisted of a ‘Lab Olympics’ competition, teambuilding exercises, talking science, having fun, and eating lots of great food! Thanks to everyone, especially Angela Lager, Olivia Corradin, and Cynthia Bartels, for making the event a great success.

May 22, 2012

Congratulations to Angela Lager for her award winning work

Tesar Lab graduate student Angela Lager has presented her work “Direct Reprogramming of Mouse Fibroblasts to Oligodendrocyte Progenitor Cells” and won the following awards: CWRU 25th Annual Biomedical Graduate Student Symposium, Vance Lemmon Award, CWRU 1st Annual Graduate Student Research Symposium, Best Poster.

Apr 23, 2012

Tesar lab graduate student Dan Factor attends conference in China

Tesar Lab graduate student Dan Factor attended and presented his work, “Epigenomic analysis identifies cell type specific regulatory elements of distinct pluripotent states” at a conference in China. The conference was Cold Spring Harbor Asia: Epigenetics, Chromatin & Transcription and held in Suzhou Dushu Lake China.

Feb 24, 2012

Tesar lab attends Gordon Research Conference in Galveston, Texas

Tesar lab graduate students Angela Lager and Bobby Karl went to sunny Galveston, Texas for the Gordon Research Conference titled, “Reprogramming Cell Fate”. Angela presented her work on reprogramming somatic cell fate into the oligodendrocyte lineage.

 

Aug 28, 2010

Paul Tesar named Robertson Investigator of the New York Stem Cell Foundation


Paul Tesar was named one of four Robertson Investigators of the New York Stem Cell Foundation (NYSCF) in 2010. The Robertson Investigator Award is awarded to early career investigators exploring the therapeutic potential of human stem cells. Winners are singled out for their potential to innovate in the field of Translational Stem Cell Research.