Therapeutic suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease in mice

2018

bioRxiv (pre-print)

Elitt MS, Barbar L, Shick E, Powers BE, Maeno-Hikitchi Y, Madhavan M, Allan KC, Nawash BS, Nevin ZS, Olsen HE, Hitomi M, LePage DF, Jiang W, Conlon RA, Rigo F, Tesar PJ.

NG2 expression in NG2 glia is regulated by binding of SoxE and bHLH transcription factors to a Cspg4 intronic enhancer

2018

Glia

Gotoh H, Wood WM, Patel KD, Factor DC, Boshans LL, Nomura T, Tesar PJ, Ono K, Nishiyama A.

Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells

2018

Nature Communications

Lager AM, Corradin OG, Cregg JM, Elitt MS, Shick HE, Clayton BLL, Allan KC, Olsen HE, Madhavan M, Tesar PJ.

Chemical screening identifies enhancers of mutant oligodendrocyte survival and unmasks a distinct pathological phase in Pelizaeus-Merzbacher disease

2018

Stem Cell Reports

Elitt MS, Shick HE, Madhavan M, Allan KC, Clayton BLL, Weng C, Miller TE, Factor DC, Barbar L, Nawash BS, Nevin ZS, Lager AM, Li Y, Jin F, Adams DJ, Tesar PJ.

Induction of myelinating oligodendrocytes in human cortical spheroids

2018

Nature Methods

Madhavan M, Nevin ZS, Shick HE, Garrison E, Clarkson-Paredes C, Karl M, Clayton BLL, Factor DC, Allan KC, Barbar L, Jain T, Douvaras P, Fossati V, Miller RH, Tesar PJ.

Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity

2018

Journal of Clinical Investigation

Chai S, Wan X, Ramirez-Navarro A, Tesar PJ, Kaufman ES, Ficker E, George AL Jr, Deschênes I.

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

2018

Nature

Hubler Z, Allimuthu D, Bederman I, Elitt MS, Madhavan M, Allan KC, Shick HE, Garrison E, T Karl M, Factor DC, Nevin ZS, Sax JL, Thompson MA, Fedorov Y, Jin J, Wilson WK, Giera M, Bracher F, Miller RH, Tesar PJ, Adams DJ.

Drug screening for human genetic diseases using iPSC models

2018

Human Molecular Genetics

Elitt MS, Barbar L, Tesar PJ.